Amplified electrocatalysis at DNA-modified nanowires

Melissa A. Lapierre-Devlin; Camille L. Asher; Bradford J. Taft; Rahela Gasparac; Marcel A. Roberts; Shana O. Kelley

doi:10.1021/nl050483a

Amplified electrocatalysis at DNA-modified nanowires

Melissa A. Lapierre-Devlin, Camille L. Asher, Bradford J. Taft, Rahela Gasparac, Marcel A. Roberts, Shana O. Kelley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Arrayed gold nanowires are a novel and useful platform for electrochemical DNA detection. Pilot studies testing the use of these templated structures with an electrocatalytic reporter system revealed that very low detection thresholds for target DNA sequences can be obtained. One factor contributing to the heightened sensitivity is the high signal-to-noise ratio achieved with the large electrocatalytic signals observed at DNA-modified nanowires. Here, we explain the improved sensitivity with evidence illustrating that electrocatalysis at DNA-modified nanostructures generates amplified signals that are significantly larger than those observed at bulk gold surfaces. The results presented strongly suggest that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion occurring around these structures. Effects unique to the nanoscale are shown to underlie the utility of nanowires for DNA biosensing.

Original language	English (US)
Pages (from-to)	1051-1055
Number of pages	5
Journal	Nano letters
Volume	5
Issue number	6
DOIs	https://doi.org/10.1021/nl050483a
State	Published - Jun 2005
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Mechanical Engineering
Bioengineering
General Materials Science

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title = "Amplified electrocatalysis at DNA-modified nanowires",

abstract = "Arrayed gold nanowires are a novel and useful platform for electrochemical DNA detection. Pilot studies testing the use of these templated structures with an electrocatalytic reporter system revealed that very low detection thresholds for target DNA sequences can be obtained. One factor contributing to the heightened sensitivity is the high signal-to-noise ratio achieved with the large electrocatalytic signals observed at DNA-modified nanowires. Here, we explain the improved sensitivity with evidence illustrating that electrocatalysis at DNA-modified nanostructures generates amplified signals that are significantly larger than those observed at bulk gold surfaces. The results presented strongly suggest that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion occurring around these structures. Effects unique to the nanoscale are shown to underlie the utility of nanowires for DNA biosensing.",

author = "Lapierre-Devlin, {Melissa A.} and Asher, {Camille L.} and Taft, {Bradford J.} and Rahela Gasparac and Roberts, {Marcel A.} and Kelley, {Shana O.}",

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TY - JOUR

T1 - Amplified electrocatalysis at DNA-modified nanowires

AU - Lapierre-Devlin, Melissa A.

AU - Asher, Camille L.

AU - Taft, Bradford J.

AU - Gasparac, Rahela

AU - Roberts, Marcel A.

AU - Kelley, Shana O.

PY - 2005/6

Y1 - 2005/6

N2 - Arrayed gold nanowires are a novel and useful platform for electrochemical DNA detection. Pilot studies testing the use of these templated structures with an electrocatalytic reporter system revealed that very low detection thresholds for target DNA sequences can be obtained. One factor contributing to the heightened sensitivity is the high signal-to-noise ratio achieved with the large electrocatalytic signals observed at DNA-modified nanowires. Here, we explain the improved sensitivity with evidence illustrating that electrocatalysis at DNA-modified nanostructures generates amplified signals that are significantly larger than those observed at bulk gold surfaces. The results presented strongly suggest that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion occurring around these structures. Effects unique to the nanoscale are shown to underlie the utility of nanowires for DNA biosensing.

AB - Arrayed gold nanowires are a novel and useful platform for electrochemical DNA detection. Pilot studies testing the use of these templated structures with an electrocatalytic reporter system revealed that very low detection thresholds for target DNA sequences can be obtained. One factor contributing to the heightened sensitivity is the high signal-to-noise ratio achieved with the large electrocatalytic signals observed at DNA-modified nanowires. Here, we explain the improved sensitivity with evidence illustrating that electrocatalysis at DNA-modified nanostructures generates amplified signals that are significantly larger than those observed at bulk gold surfaces. The results presented strongly suggest that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion occurring around these structures. Effects unique to the nanoscale are shown to underlie the utility of nanowires for DNA biosensing.

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Amplified electrocatalysis at DNA-modified nanowires

Abstract

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