Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing

Melissa A. Lapierre-Devlin, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review


Three-dimensional gold nanowire ensembles (NEE) are a novel and useful platform for electrochemical DNA detection. Work performed in our laboratory using the three-dimensional nanostructures with an electrocatalytic reporter system has produced attomole sensitivity towards target DNA sequences. Large electrocatalytic signals observed at DNAmodified nanowires produce high signal-to-noise ratios, which is one factor that contributes to the improved sensitivity. DNA-modified nanostructures generate amplified electrocatalysis signals that are significantly larger than those observed at bulk gold surfaces, and our experiments indicate that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion and accessibility occurring around these structures. The heightened sensitivity achieved indicates that the nanowire ensembles constitute a promising platform for ultrasensitive biosensors.

Original languageEnglish (US)
Article number600705
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2005
Externally publishedYes
EventSmart Medical and Biomedical Sensor Technology III - Boston, MA, United States
Duration: Oct 24 2005Oct 26 2005


  • DNA-modified nanostructures
  • Electrochemical detection
  • Ultrasensitive DNA biosensing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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