Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment

Anthony Burgos-Robles, Eyal Y. Kimchi, Ehsan M. Izadmehr, Mary Jane Porzenheim, William A. Ramos-Guasp, Edward H. Nieh, Ada C. Felix-Ortiz, Praneeth Namburi, Christopher A. Leppla, Kara N. Presbrey, Kavitha K. Anandalingam, Pablo A. Pagan-Rivera, Melodi Anahtar, Anna Beyeler, Kay M. Tye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

151 Scopus citations

Abstract

Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA→PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals.

Original languageEnglish (US)
Pages (from-to)824-835
Number of pages12
JournalNature neuroscience
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2017

ASJC Scopus subject areas

  • Neuroscience(all)

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