An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

Peter Mombaerts; Steven J. Anderson; Roger M. Perlmutter; Tak W. Mak; Susumu Tonegawa

doi:10.1016/1074-7613(94)90077-9

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

Peter Mombaerts^*, Steven J. Anderson, Roger M. Perlmutter, Tak W. Mak, Susumu Tonegawa

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

Expression of the T cell receptor β (TCRβ) chain is necessary for the transition from the CD4^-CD8^- stage in the major up thymocyte lineage. The protein tyrosine kinase p56^lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCRβ locus. Using mice overexpressing an activated lck transgene and mice with a disruption of the lck gene, we demonstrate that p56 ^lck participates in a pathway that regulates the expansion of the pool of CD4⁺CD8⁺ thymocytes to wild-type levels. In addition, p56^lck may be involved in the down-regulation of the putative pre-TCR on CD4⁺CD8⁺ thymocytes.

Original language	English (US)
Pages (from-to)	261-267
Number of pages	7
Journal	Immunity
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/1074-7613(94)90077-9
State	Published - Jul 1994

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/1074-7613(94)90077-9

Cite this

@article{88228896420c4876a1804ba88e36aba2,

title = "An activated Ick transgene promotes thymocyte development in rag-1 mutant mice",

abstract = "Expression of the T cell receptor β (TCRβ) chain is necessary for the transition from the CD4-CD8- stage in the major up thymocyte lineage. The protein tyrosine kinase p56lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCRβ locus. Using mice overexpressing an activated lck transgene and mice with a disruption of the lck gene, we demonstrate that p56 lck participates in a pathway that regulates the expansion of the pool of CD4+CD8+ thymocytes to wild-type levels. In addition, p56lck may be involved in the down-regulation of the putative pre-TCR on CD4+CD8+ thymocytes.",

author = "Peter Mombaerts and Anderson, {Steven J.} and Perlmutter, {Roger M.} and Mak, {Tak W.} and Susumu Tonegawa",

note = "Funding Information: We thank R. Axe1 and C. Levelt for useful comments, and B. Williams for technical assistance. P. M. wasa Howard Hughes Medical institute Predoctoral Fellow in Biological Sciences. Grant support was from Howard Hughes Medical Institute and the National Institutes of Health.",

year = "1994",

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doi = "10.1016/1074-7613(94)90077-9",

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pages = "261--267",

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T1 - An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

AU - Mombaerts, Peter

AU - Anderson, Steven J.

AU - Perlmutter, Roger M.

AU - Mak, Tak W.

AU - Tonegawa, Susumu

N1 - Funding Information: We thank R. Axe1 and C. Levelt for useful comments, and B. Williams for technical assistance. P. M. wasa Howard Hughes Medical institute Predoctoral Fellow in Biological Sciences. Grant support was from Howard Hughes Medical Institute and the National Institutes of Health.

PY - 1994/7

Y1 - 1994/7

N2 - Expression of the T cell receptor β (TCRβ) chain is necessary for the transition from the CD4-CD8- stage in the major up thymocyte lineage. The protein tyrosine kinase p56lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCRβ locus. Using mice overexpressing an activated lck transgene and mice with a disruption of the lck gene, we demonstrate that p56 lck participates in a pathway that regulates the expansion of the pool of CD4+CD8+ thymocytes to wild-type levels. In addition, p56lck may be involved in the down-regulation of the putative pre-TCR on CD4+CD8+ thymocytes.

AB - Expression of the T cell receptor β (TCRβ) chain is necessary for the transition from the CD4-CD8- stage in the major up thymocyte lineage. The protein tyrosine kinase p56lck has been implicated in the regulation of early thymocyte differentiation and of allelic exclusion at the TCRβ locus. Using mice overexpressing an activated lck transgene and mice with a disruption of the lck gene, we demonstrate that p56 lck participates in a pathway that regulates the expansion of the pool of CD4+CD8+ thymocytes to wild-type levels. In addition, p56lck may be involved in the down-regulation of the putative pre-TCR on CD4+CD8+ thymocytes.

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JF - Immunity

SN - 1074-7613

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ER -

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

Abstract

ASJC Scopus subject areas

UN SDGs

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