An aggressive surgical approach is warranted in the management of cystic pancreatic neoplasms

Jeffrey M. Hardacre*, Michael F. McGee, Thomas A. Stellato, James A. Schulak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background: Cystic pancreatic neoplasms encompass a range of benign to malignant disease. Recommendations for surgical management vary. Methods: Records of patients with cystic pancreatic neoplasms from January 1996 through December 2005 were retrospectively reviewed. Results: Sixty resections were performed for 16 serous cystic neoplasms, 7 mucinous cystic neoplasms (MCNs), and 37 intraductal papillary mucinous neoplasms (IPMNs). Twenty-five percent (15/60) of neoplasms contained invasive cancer. Patients with MCN or IPMN invasive neoplasms experienced significantly diminished overall 5-year survival compared to patients with IPMN carcinoma in situ neoplasms and to patients with MCN or IPMN adenoma/borderline neoplasms (22% vs. 73% vs. 94%, P = .004). Conclusions: Given the poor long-term survival of patients with cystic pancreatic neoplasms containing invasive cancer and the current difficulty to preoperatively distinguish among the various types of lesions in a reliable manner, our data support an aggressive surgical approach to the management of cystic pancreatic neoplasms.

Original languageEnglish (US)
Pages (from-to)374-379
Number of pages6
JournalAmerican journal of surgery
Volume193
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Cystic pancreatic neoplasm
  • Intraductal papillary mucinous neoplasm
  • Mucinous cystic neoplasm
  • Serous cystic neoplasm

ASJC Scopus subject areas

  • Surgery

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