In this paper, we will propose PC-Cleaner (PC stands for Partition Comparison), a novel technique for effective and efficient duplicate record detection in the large database collection. PC-Cleaner distinguishes itself from all of existing methods by using the notion of partition in duplicate detection. It first sorts the whole database and splits the sorted database into a number of record partitions. The Partition Comparison Graph (PCG) is then generated by performing fast partition pruning. Finally, duplicate records are effectively detected by using internal and external partition comparison based on the PCG. Four properties, used as heuristics, have been devised to achieve a remarkable efficiency improvement of the cleaner based on triangle inequity of record similarity. PC-Cleaner is insensitive to the key used to sort the database and can achieve a very good recall level that is comparable to that of the pair-wise record comparison method. PC-Cleaner is able to well solve the "Key Selection" problem and the "Low Recall" problem that the existing methods suffer.