An efficient and highly enantio- and diastereoselective cyclopropanation of olefins catalyzed by Schiff-base ruthenium(II) complexes

Jason A. Miller, Wiechang Jin, Sonbinh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

Both electron-rich and electron-deficient olefins - such as styrene and methyl methacrylate - undergo efficient (yields > 90%) cyclopropanation with ethyl diazoacetate as the carbene source to give predominantly trans products with exceptionally high enantioselectivity when the (salen)Ru catalyst shown is used (see scheme).

Original languageEnglish (US)
Pages (from-to)2953-2956
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number16
DOIs
StatePublished - Aug 16 2002

Keywords

  • Asymmetric catalysis
  • Cyclopropanation
  • N,O ligands
  • Ruthenium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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