An efficient artificial molecular pump

Cristian Pezzato, Minh T. Nguyen, Chuyang Cheng, Dong Jun Kim, Michael T. Otley, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Scopus citations


Despite the fact that artificial molecular machines are on the rise, there is a long way to go to eventually fill the yawning gap that exists between biological and man-made machines in terms of both their mechanisms of action and efficiencies of operation. Herein, we describe our recent efforts directed towards the development of a second-generation (more efficient) artificial molecular pump – a wholly synthetic compound, which operates to compartmentalise highly charged rings in a high-energy state on an oligomethylene chain. The optimized artificial molecular pump operates rapidly, thanks to well-tuned noncovalent bonding interactions, paving the way to address enthalpically and entropically demanding polymers that would be difficult to obtain with the available repertoire of synthetic methods.

Original languageEnglish (US)
Pages (from-to)4849-4857
Number of pages9
Issue number33
StatePublished - 2017


  • Artificial molecular machines
  • Energy ratchet
  • Non-equilibrium processes
  • Redox chemistry
  • Rotaxanes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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