An efficient method for the chemoselective synthesis of acylals from aromatic aldehydes using bismuth triflate

Marc D. Carrigan, Kyle J. Eash, Matthew C. Oswald, Ram S. Mohan

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

Aromatic aldehydes are smoothly converted into the corresponding acylals in good yields in the presence of 0.10 mol% Bi(OTf)3·xH2O. Ketones are not affected under the reaction conditions. The highly catalytic nature of bismuth triflate and the fact that it is relatively non-toxic, easy to handle and insensitive to small amounts of air and moisture makes this procedure especially attractive for large-scale synthesis.

Original languageEnglish (US)
Pages (from-to)8133-8135
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number46
DOIs
StatePublished - Nov 12 2001

Keywords

  • Acylals
  • Acylation
  • Bismuth and compounds
  • Protecting groups

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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