Abstract
Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5×0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97°C throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 39-46 |
| Number of pages | 8 |
| Journal | Open Biomedical Engineering Journal |
| Volume | 4 |
| Issue number | SPEC. ISSUE 1 |
| State | Published - Nov 19 2010 |
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ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
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An electrode array for limiting blood loss during liver resection : Optimization via mathematical modeling. / Strigel, R. M.; Schutt, D. J.; Webster, J. G.; Mahvi, D. M.; Haemmerich, D.
In: Open Biomedical Engineering Journal, Vol. 4, No. SPEC. ISSUE 1, 19.11.2010, p. 39-46.Research output: Contribution to journal › Article
TY - JOUR
T1 - An electrode array for limiting blood loss during liver resection
T2 - Optimization via mathematical modeling
AU - Strigel, R. M.
AU - Schutt, D. J.
AU - Webster, J. G.
AU - Mahvi, D. M.
AU - Haemmerich, D.
PY - 2010/11/19
Y1 - 2010/11/19
N2 - Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5×0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97°C throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels.
AB - Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5×0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97°C throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels.
UR - http://www.scopus.com/inward/record.url?scp=78249268271&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78249268271&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:78249268271
VL - 4
SP - 39
EP - 46
JO - Open Biomedical Engineering Journal
JF - Open Biomedical Engineering Journal
SN - 1874-1207
IS - SPEC. ISSUE 1
ER -