An electrode array for limiting blood loss during liver resection: Optimization via mathematical modeling

R. M. Strigel, D. J. Schutt, J. G. Webster, D. M. Mahvi, D. Haemmerich*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5×0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97°C throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalOpen Biomedical Engineering Journal
Volume4
Issue numberSPEC. ISSUE 1
StatePublished - Nov 19 2010

Fingerprint

Liver
Electrodes
Blood
Coagulation
Tissue
Temperature
Mortality
Electric currents
Liver Neoplasms
Blood Transfusion
Needles
Temperature distribution
Current density
Hot Temperature
Morbidity
Finite element method
Equipment and Supplies
Survival

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Strigel, R. M., Schutt, D. J., Webster, J. G., Mahvi, D. M., & Haemmerich, D. (2010). An electrode array for limiting blood loss during liver resection: Optimization via mathematical modeling. Open Biomedical Engineering Journal, 4(SPEC. ISSUE 1), 39-46.
Strigel, R. M. ; Schutt, D. J. ; Webster, J. G. ; Mahvi, D. M. ; Haemmerich, D. / An electrode array for limiting blood loss during liver resection : Optimization via mathematical modeling. In: Open Biomedical Engineering Journal. 2010 ; Vol. 4, No. SPEC. ISSUE 1. pp. 39-46.
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Strigel, RM, Schutt, DJ, Webster, JG, Mahvi, DM & Haemmerich, D 2010, 'An electrode array for limiting blood loss during liver resection: Optimization via mathematical modeling', Open Biomedical Engineering Journal, vol. 4, no. SPEC. ISSUE 1, pp. 39-46.

An electrode array for limiting blood loss during liver resection : Optimization via mathematical modeling. / Strigel, R. M.; Schutt, D. J.; Webster, J. G.; Mahvi, D. M.; Haemmerich, D.

In: Open Biomedical Engineering Journal, Vol. 4, No. SPEC. ISSUE 1, 19.11.2010, p. 39-46.

Research output: Contribution to journalArticle

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Strigel RM, Schutt DJ, Webster JG, Mahvi DM, Haemmerich D. An electrode array for limiting blood loss during liver resection: Optimization via mathematical modeling. Open Biomedical Engineering Journal. 2010 Nov 19;4(SPEC. ISSUE 1):39-46.