An electrophysiological index of stimulus unfamiliarity

Kirk R. Daffner*, M. Marsel Mesulam, Leonard F.M. Scinto, Vivian Calvo, Robert Faust, Phillip J. Holcomb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

This study investigated the functional significance of the N2 response to novel stimuli. In one condition, background, target, and deviant stimuli were simple geometric figures. In a second condition, all stimulus types were unfamiliar/unusual figures. In a third condition, background and target stimuli were unusual figures and deviant stimuli were simple shapes. Unusual figures, whether they were deviant, target, or background stimuli, evoked larger N2 responses than their simple, familiar counterparts. N2 elicited by an unusual background stimulus was larger than that evoked by simple, deviant stimuli, a pattern opposite that exhibited by the subsequent P3. Deviance from immediate context had limited influence over N2 amplitude. The results suggest that novelty N2 and novelty P3 reflect the processing of different aspects of 'novel' visual stimuli. The novelty P3 is particularly sensitive to deviation from immediate context. In contrast, the novelty N2 is sensitive to deviation from long-term context that renders a stimulus unfamiliar and difficult to encode.

Original languageEnglish (US)
Pages (from-to)737-747
Number of pages11
JournalPsychophysiology
Volume37
Issue number6
DOIs
StatePublished - 2000

Keywords

  • ERPs
  • N2
  • Novelty processing
  • P3
  • Stimulus deviance
  • Stimulus unfamiliarity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

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