An empirical approach to estimate near-infra-red photon propagation and optically induced drug release in brain tissues

Akshay Prabhu Verleker, Qianqian Fang, Mi Ran Choi, Susan Clare, Keith M. Stantz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

The purpose of this study is to develop an alternate empirical approach to estimate near-infra-red (NIR) photon propagation and quantify optically induced drug release in brain metastasis, without relying on computationally expensive Monte Carlo techniques (gold standard). Targeted drug delivery with optically induced drug release is a noninvasive means to treat cancers and metastasis. This study is part of a larger project to treat brain metastasis by delivering lapatinib-drug-nanocomplexes and activating NIR-induced drug release. The empirical model was developed using a weighted approach to estimate photon scattering in tissues and calibrated using a GPU based 3D Monte Carlo. The empirical model was developed and tested against Monte Carlo in optical brain phantoms for pencil beams (width 1mm) and broad beams (width 10mm). The empirical algorithm was tested against the Monte Carlo for different albedos along with diffusion equation and in simulated brain phantoms resembling white-matter (μs=8.25mm-1, μa=0.005mm-1) and gray-matter (μs=2.45mm-1, μa=0.035mm-1) at wavelength 800nm. The goodness of fit between the two models was determined using coefficient of determination (R-squared analysis). Preliminary results show the Empirical algorithm matches Monte Carlo simulated fluence over a wide range of albedo (0.7 to 0.99), while the diffusion equation fails for lower albedo. The photon fluence generated by empirical code matched the Monte Carlo in homogeneous phantoms (R2=0.99). While GPU based Monte Carlo achieved 300X acceleration compared to earlier CPU based models, the empirical code is 700X faster than the Monte Carlo for a typical super-Gaussian laser beam.

Original languageEnglish (US)
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XXIV
EditorsDavid H. Kessel, Tayyaba Hasan
PublisherSPIE
ISBN (Electronic)9781628413984
DOIs
StatePublished - Jan 1 2015
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV - San Francisco, United States
Duration: Feb 7 2015Feb 9 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9308
ISSN (Print)1605-7422

Other

OtherOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
CountryUnited States
CitySan Francisco
Period2/7/152/9/15

Keywords

  • Empirical algorithm for light propagation
  • Light Scattering
  • Monte Carlo simulation
  • NIR photon propagation
  • Optical therapy
  • Optically induced drug release
  • Tissue Optics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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