An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment

Hyunjae Lee, Youngsik Lee, Changyeong Song, Hye Rim Cho, Roozbeh Ghaffari, Tae Kyu Choi, Kyung Hoon Kim, Young Bum Lee, Daishun Ling, Hyuk Lee, Su Jong Yu, Seung Hong Choi*, Taeghwan Hyeon, Dae Hyeong Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions.

Original languageEnglish (US)
Article number10059
JournalNature communications
Volume6
DOIs
StatePublished - Nov 30 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Lee, H., Lee, Y., Song, C., Cho, H. R., Ghaffari, R., Choi, T. K., Kim, K. H., Lee, Y. B., Ling, D., Lee, H., Yu, S. J., Choi, S. H., Hyeon, T., & Kim, D. H. (2015). An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment. Nature communications, 6, [10059]. https://doi.org/10.1038/ncomms10059