An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth

Keyphrases

• Tumor Growth 100%
• Inhibit Tumor 100%
• Wild-type KRAS 100%
• Chimeric Toxin 100%
• Small Molecules 50%
• Mouse Xenograft Model 50%
• Tumor Burden 50%
• Downstream Signaling 50%
• Receptor-mediated 50%
• Oncogenic Ras 50%
• Target Engagement 50%
• Rap1 50%
• Diphtheria Toxin 50%
• Endopeptidase 50%
• Protein Delivery 50%
• Intracellular Delivery 50%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Tumor Progression 100%
• Small Molecule 50%
• Tumor Volume 50%
• Diphtheria Toxin 50%
• Protease 50%