An evaluation of the efficacy and tolerability of oral tramadol hydrochloride tablets for the treatment of postsurgical pain in children

Julia C. Finkel*, John B. Rose, Michael L. Schmitz, Patrick K. Birmingham, George A. Ulma, Joel B. Gunter, Avital Cnaan, Charles J. Coté, Robert A. Medve, Mark S. Schreiner

*Corresponding author for this work

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Abstract

In this double-blinded, randomized, multicenter study, we examined analgesic efficacy and tolerability of tramadol in postoperative pediatric patients. Eighty-one postsurgical ASA physical status I and II patients ages 7-16 yr received oral tramadol (approximately 1 or 2 mg/kg) for postoperative analgesia when they were ready to transition from morphine patient-controlled analgesia to oral analgesics. Rescue analgesia consisted of morphine patient-controlled analgesia or an oral equivalent dose of oxycodone. Patients rated their pain just before the administration of tramadol and at regular intervals for 8 h afterwards using the Wong-Baker Faces Pain Rating Scale. The 2-mg/kg group required approximately half as much rescue analgesia as the 1-mg/kg group (P = 0.006). Parents rated the larger dose more favorably. Adverse events were generally mild to moderate in severity (vomiting [10%], nausea [9%], pruritus [7%], rash [4%]) and similar between the two treatment groups. There were no significant changes in hemodynamic variables, respiratory rate, or Spo2 percentages between the two treatment groups or in all patients compared with pretreatment values.

Original languageEnglish (US)
Pages (from-to)1469-1473
Number of pages5
JournalAnesthesia and analgesia
Volume94
Issue number6
StatePublished - Jun 5 2002

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ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Finkel, J. C., Rose, J. B., Schmitz, M. L., Birmingham, P. K., Ulma, G. A., Gunter, J. B., Cnaan, A., Coté, C. J., Medve, R. A., & Schreiner, M. S. (2002). An evaluation of the efficacy and tolerability of oral tramadol hydrochloride tablets for the treatment of postsurgical pain in children. Anesthesia and analgesia, 94(6), 1469-1473.