TY - JOUR
T1 - An evaluation of the use of new Doppler methods for detecting longitudinal function abnormalities in a pacing-induced heart failure model
AU - Tabata, Tomotsugu
AU - Cardon, Lisa A.
AU - Armstrong, Guy P.
AU - Fukamach, Kiyotaka
AU - Takagaki, Masami
AU - Ochiai, Yoshie
AU - McCarthy, Patrick M.
AU - Thomas, James D.
N1 - Funding Information:
Supported in part by Grant NCC 9-60, National Aeronautics and Space Administration, Houston, Texas (J.D.T.), and a grant from Myocor Inc, Plymouth, Minn. Original article
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Background: Doppler tissue echocardiography and color M-mode Doppler flow propagation velocity have proven useful in evaluating cross-sections of patients with left ventricular (LV) dysfunction, but experience with serial changes is limited. Purpose and Methods: We tested their use by evaluating the temporal changes of LV function in a pacing-induced congestive heart failure model. Rapid ventricular pacing was initiated and maintained in 20 dogs for 4 weeks. Echocardiography was performed at baseline and weekly during brief pacing cessation. Results: With rapid pacing, LV volume significantly increased and ejection fraction (57%-28%), stroke volume (37-18 mL), and mitral annulus systolic velocity (16.1-6.6 cm/s) by Doppler tissue echocardiography significantly decreased, with ejection fraction and mitral annulus systolic velocity closely correlated (r = 0.706, P < .0001). In contrast to the mitral inflow velocities, mitral annulus early diastolic velocity decreased steadily (12.3-7.3 cm/s) resulting in a dramatic decrease in mitral annulus early/late (1.22-0.57) diastolic velocity with no tendency toward pseudonormalization. The color M-mode Doppler flow propagation velocity also showed significant steady decrease (57-24 cm/s) throughout the pacing period. Multiple regression analysis chose mitral annulus systolic velocity (r = 0.895, P < .0001) and propagation velocity (r = 0.782, P < .0001) for the most important factor predicting LV systolic and diastolic function, respectively. Conclusions: Doppler tissue echocardiography and color M-mode Doppler flow could evaluate the serial deterioration in LV dysfunction throughout the pacing period. These were more useful in quantifying progressive LV dysfunction than conventional ehocardiographic techniques, and were probably relatively independent of preload. These techniques could be suitable for longitudinal evaluation in addition to the cross-sectional study.
AB - Background: Doppler tissue echocardiography and color M-mode Doppler flow propagation velocity have proven useful in evaluating cross-sections of patients with left ventricular (LV) dysfunction, but experience with serial changes is limited. Purpose and Methods: We tested their use by evaluating the temporal changes of LV function in a pacing-induced congestive heart failure model. Rapid ventricular pacing was initiated and maintained in 20 dogs for 4 weeks. Echocardiography was performed at baseline and weekly during brief pacing cessation. Results: With rapid pacing, LV volume significantly increased and ejection fraction (57%-28%), stroke volume (37-18 mL), and mitral annulus systolic velocity (16.1-6.6 cm/s) by Doppler tissue echocardiography significantly decreased, with ejection fraction and mitral annulus systolic velocity closely correlated (r = 0.706, P < .0001). In contrast to the mitral inflow velocities, mitral annulus early diastolic velocity decreased steadily (12.3-7.3 cm/s) resulting in a dramatic decrease in mitral annulus early/late (1.22-0.57) diastolic velocity with no tendency toward pseudonormalization. The color M-mode Doppler flow propagation velocity also showed significant steady decrease (57-24 cm/s) throughout the pacing period. Multiple regression analysis chose mitral annulus systolic velocity (r = 0.895, P < .0001) and propagation velocity (r = 0.782, P < .0001) for the most important factor predicting LV systolic and diastolic function, respectively. Conclusions: Doppler tissue echocardiography and color M-mode Doppler flow could evaluate the serial deterioration in LV dysfunction throughout the pacing period. These were more useful in quantifying progressive LV dysfunction than conventional ehocardiographic techniques, and were probably relatively independent of preload. These techniques could be suitable for longitudinal evaluation in addition to the cross-sectional study.
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U2 - 10.1016/S0894-7317(03)00083-X
DO - 10.1016/S0894-7317(03)00083-X
M3 - Article
C2 - 12724650
AN - SCOPUS:0038558165
SN - 0894-7317
VL - 16
SP - 424
EP - 431
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 5
ER -
