TY - JOUR
T1 - An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease
AU - Azi, Mansoor S Arfar
AU - Upadhyaya, Meena
AU - Padberg, George
AU - Pericak-Vance, Margaret
AU - Siddique, Teepu
AU - Lucotte, G.
AU - Lunt, Peter
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - By using the genetic linkage data between the facioscapulohumeral muscular dystrophy (FSHD) gene and 57 markers on various autosomes, we have constructed an exclusion map for this disorder. The maximum likelihood location of the FSHD gene and the percentage of the excluded areas on each chromosome are presented here. This exclusion map shows that more than 80% of the genome has been excluded as a likely location of any locus responsible for FSHD in the majority of families. Chromosomes 3, 5, 10, 11, 15, and 19 remain largely unexcluded. Concentration on the highlighted areas of the genome should facilitate the identification of the site of the FSHD gene.
AB - By using the genetic linkage data between the facioscapulohumeral muscular dystrophy (FSHD) gene and 57 markers on various autosomes, we have constructed an exclusion map for this disorder. The maximum likelihood location of the FSHD gene and the percentage of the excluded areas on each chromosome are presented here. This exclusion map shows that more than 80% of the genome has been excluded as a likely location of any locus responsible for FSHD in the majority of families. Chromosomes 3, 5, 10, 11, 15, and 19 remain largely unexcluded. Concentration on the highlighted areas of the genome should facilitate the identification of the site of the FSHD gene.
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U2 - 10.1136/jmg.26.8.481
DO - 10.1136/jmg.26.8.481
M3 - Article
C2 - 2769720
AN - SCOPUS:0024321693
SN - 0022-2593
VL - 26
SP - 481
EP - 484
JO - Journal of medical genetics
JF - Journal of medical genetics
IS - 8
ER -