An expanding job description for Blimp-1/PRDM1

Elizabeth K. Bikoff*, Marc A. Morgan, Elizabeth J. Robertson

*Corresponding author for this work

Research output: Contribution to journalReview article

73 Scopus citations

Abstract

The master transcriptional regulator Blimp-1/PRDM1 contains an N-terminal PR/SET domain and five C2H2 zinc fingers located near its C-terminus that mediate DNA binding, nuclear import and recruitment of histone modifying enzymes. These activities account for its ability to control cell-fate decisions in the embryo and govern tissue homeostasis in multiple cell types in the adult organism. New experiments demonstrate an increasing degree of complexity associated with Blimp-1/PRDM1 target site selection and its associations with epigenetic modifiers. Our current understanding of how this single unique species within the family of structurally similar PRDM proteins regulates gene expression patterns and governs developmental programmes in different cell lineages is discussed.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume19
Issue number4
DOIs
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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