An expanding job description for Blimp-1/PRDM1

Elizabeth K. Bikoff; Marc A. Morgan; Elizabeth J. Robertson

doi:10.1016/j.gde.2009.05.005

An expanding job description for Blimp-1/PRDM1

Elizabeth K. Bikoff^*, Marc A. Morgan, Elizabeth J. Robertson

^*Corresponding author for this work

Biochemistry and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

The master transcriptional regulator Blimp-1/PRDM1 contains an N-terminal PR/SET domain and five C2H2 zinc fingers located near its C-terminus that mediate DNA binding, nuclear import and recruitment of histone modifying enzymes. These activities account for its ability to control cell-fate decisions in the embryo and govern tissue homeostasis in multiple cell types in the adult organism. New experiments demonstrate an increasing degree of complexity associated with Blimp-1/PRDM1 target site selection and its associations with epigenetic modifiers. Our current understanding of how this single unique species within the family of structurally similar PRDM proteins regulates gene expression patterns and governs developmental programmes in different cell lineages is discussed.

Original language	English (US)
Pages (from-to)	379-385
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.gde.2009.05.005
State	Published - Aug 2009

Funding

Work in our lab is supported by grants from the Wellcome Trust. EJR is Wellcome Trust Principal Research Fellow.

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2009.05.005

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title = "An expanding job description for Blimp-1/PRDM1",

abstract = "The master transcriptional regulator Blimp-1/PRDM1 contains an N-terminal PR/SET domain and five C2H2 zinc fingers located near its C-terminus that mediate DNA binding, nuclear import and recruitment of histone modifying enzymes. These activities account for its ability to control cell-fate decisions in the embryo and govern tissue homeostasis in multiple cell types in the adult organism. New experiments demonstrate an increasing degree of complexity associated with Blimp-1/PRDM1 target site selection and its associations with epigenetic modifiers. Our current understanding of how this single unique species within the family of structurally similar PRDM proteins regulates gene expression patterns and governs developmental programmes in different cell lineages is discussed.",

author = "Bikoff, {Elizabeth K.} and Morgan, {Marc A.} and Robertson, {Elizabeth J.}",

note = "Funding Information: Work in our lab is supported by grants from the Wellcome Trust. EJR is Wellcome Trust Principal Research Fellow.",

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AU - Morgan, Marc A.

AU - Robertson, Elizabeth J.

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AB - The master transcriptional regulator Blimp-1/PRDM1 contains an N-terminal PR/SET domain and five C2H2 zinc fingers located near its C-terminus that mediate DNA binding, nuclear import and recruitment of histone modifying enzymes. These activities account for its ability to control cell-fate decisions in the embryo and govern tissue homeostasis in multiple cell types in the adult organism. New experiments demonstrate an increasing degree of complexity associated with Blimp-1/PRDM1 target site selection and its associations with epigenetic modifiers. Our current understanding of how this single unique species within the family of structurally similar PRDM proteins regulates gene expression patterns and governs developmental programmes in different cell lineages is discussed.

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An expanding job description for Blimp-1/PRDM1

Abstract

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ASJC Scopus subject areas

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