An extended model of intrapleural fluid flow and iransport

J. Grotberg*, R. Haber, Matthew R Glucksberg

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We have extended our mathematical model of intrapleural fluid mechanics which consists of two nested cylinders, the inner cylinder representing the lung and the outer cylinder the chest wall. The analysis, in general, balances fluid and lung buoyancy forces. The extension of the flow conditions includes transparietal fluid flow and, separately, lymphatic drainage. The lung model is improved to treat it as a flexible boundary and its effects on the flow and balance with buoyancy are delineated. Also, small amplitude oscillations of the cylinder radii, such as occur in breathing, are incorporated to evaluate their net effects on intrapleural flow, pressure distribution and dynamics, The various governing equations are solved using techniques of asymptotic analysis for thin viscous layers and numerical methods. Of the major results, one finding for steady state, apneic, conditions is that a range of parameters allows for non-contact between the cylinders, while other ranges require contact for the forces to the balance. The lung flexibility modifies this range, as well as the intrapleural pressure in steady and unsteady states.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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