An I47L substitution in the HOXD13 homeodomain causes a novel human limb malformation by producing a selective loss of function

INIS

• proteins 100%
• limbs 83%
• mutations 66%
• humans 50%
• dna 50%
• genes 50%
• mutants 50%
• malformations 50%
• phenotype 33%
• losses 33%
• in vivo 16%
• in vitro 16%
• interactions 16%
• gain 16%
• comparative evaluations 16%
• morphology 16%
• suppression 16%
• cartilage 16%
• expansion 16%
• transcription factors 16%
• vertebrates 16%
• leucine 16%

Biochemistry, Genetics and Molecular Biology

• Wild Type 83%
• Protein 50%
• Mutation 33%
• Phenotype 33%
• Missense Mutation 33%
• DNA Binding 33%
• Homeodomain 33%
• Chick 33%
• Mutant 33%
• Nested Gene 16%
• Isoleucine 16%
• Leucine 16%
• Transcription Factor 16%
• Gene Cluster 16%
• Protein-Protein Interaction 16%
• Morphology 16%
• Mutant Protein 16%
• Retrovirus 16%
• Hox Gene 16%
• Limb Development 16%
• DNA 16%
• Position 16%