An IGFBP2-derived peptide promotes neuroplasticity and rescues deficits in a mouse model of Phelan-McDermid syndrome

Keyphrases

• Mouse Model 100%
• Derived Peptide 100%
• Neuroplasticity 100%
• Insulin-like Growth Factor 2 mRNA-binding Protein 2 (IGF2BP2) 100%
• Phelan-McDermid Syndrome 100%
• Synaptic Plasticity 66%
• Autism Spectrum Disorder 66%
• SHANK3 66%
• Gene Transcription 33%
• Motor Behavior 33%
• Synapse 33%
• Risk Factors 33%
• Human Subjects 33%
• Therapeutic Potential 33%
• Neuronal Excitability 33%
• Translational Value 33%
• Dendrite 33%
• N-methyl-D-aspartate Receptor (NMDAR) 33%
• Receptor Activation 33%
• Phosphoproteomics 33%
• Functional Plasticity 33%
• Insulin-like Growth Factor 1 Receptor (IGF1R) 33%
• Associated Proteins 33%
• Steady State 33%
• Haploinsufficiency 33%
• Motor Function 33%
• Sensory Processing 33%
• Cognitive Function 33%
• Cytoskeletal Regulation 33%
• Cultured Neurons 33%
• Seizure Susceptibility 33%
• Language Functioning 33%
• Autism 33%
• Gene Translation 33%
• Synaptic Function 33%
• Protein Network 33%
• Response Latency 33%
• Multiple Diseases 33%
• Response Measures 33%
• Biological Activity 33%
• Processing Language 33%
• Electroencephalography 33%
• Mimetic Peptide 33%
• Heterozygous Mice 33%
• Peptide Fragments 33%
• Processing Function 33%
• Insulin-like Growth Factor 2 (IGF2) 33%
• Ultrasonic Vocalization 33%
• Auditory Evoked Response 33%
• Alpha Frequency 33%
• Ultrasonic Motor 33%
• SHANK3 Gene 33%
• Synapse Regulation 33%

Neuroscience

• Synapse 100%
• Neuroplasticity 100%
• Pervasive Developmental Disorder 100%
• Receptor 100%
• Sensory Processing 50%
• Electroencephalography 50%
• Insulin-Like Growth Factor 1 50%
• Neuronal Excitability 50%
• Dendrite 50%
• Amino Acid Activation 50%
• Ultrasonic Vocalization 50%
• Behavior (Neuroscience) 50%
• Cognitive Function 50%
• NMDA Receptor 50%
• Haploinsufficiency 50%
• Genetic Transcription 50%
• Auditory Evoked Potential 50%
• Peptide Fragment 50%
• Comorbidity 50%

Biochemistry, Genetics and Molecular Biology

• Mouse Model 100%
• IGFBP2 100%
• 22q13 Deletion Syndrome 100%
• Synapse 66%
• Ultrasound 33%
• Peptide Mimetics 33%
• SHANK3 33%
• Genetic Transcription 33%
• Human 33%
• Steady State 33%
• Locomotion 33%
• Haploinsufficiency 33%
• Biological Activity 33%
• Excitability 33%
• Nerve Cell Culture 33%
• RNA Translation 33%
• Reaction Time 33%
• Motor Performance 33%
• Vocalization 33%
• Language Processing 33%
• Auditory Evoked Potential 33%
• Insulin-Like Growth Factor 1 33%
• NMDA Receptor 33%
• Cognition 33%
• Comorbidity 33%