An Infectious Diseases Perspective on Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children

Jillian M. Cotter, Maribeth R. Nicholson, Larry K. Kociolek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Fecal microbiota transplantation (FMT) is efficacious for treatment of recurrent Clostridioides difficile infections (rCDIs). Pediatric experience with FMT for rCDIs is increasing, particularly at large centers. While retrospective studies suggest that FMT is generally safe in the short term, particularly in immunocompetent patients and with rigorous donor screening, additional large prospective studies are needed. This particularly includes those at high risk for infectious complications, such as immunocompromised hosts. Further, long-term implications of altering the intestinal microbiome with FMT are not well understood. The role of FMT in children, particularly in high-risk patients, will require continual reexamination with future availability of pediatric safety and efficacy data. This review summarizes key points for infectious diseases physicians to consider when evaluating a child for FMT.

Original languageEnglish (US)
Pages (from-to)580-584
Number of pages5
JournalJournal of the Pediatric Infectious Diseases Society
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2019

Keywords

  • Clostridioides difficile
  • Clostridium difficile
  • fecal microbiota transplantation
  • safety
  • screening

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'An Infectious Diseases Perspective on Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children'. Together they form a unique fingerprint.

Cite this