An inhibitor of a cell adhesion receptor stimulates cell migration

Shagufta H. Shabbir, Jessica L. Eisenberg, Milan Mrksich

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Making cells get a move on: The integrins are cell-surface receptors that mediate the adhesion and migration of cells on a protein matrix. An open question is whether addition of an inhibitor of the receptor slows or accelerates cell migration. By using self-assembled monolayers presenting a cell adhesion ligand as a model system it is found that an inhibitor (RGD peptide) can stimulate cell migration.

Original languageEnglish (US)
Pages (from-to)7706-7709
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number42
DOIs
StatePublished - Oct 11 2010

Keywords

  • Cell adhesion
  • Inhibitors
  • Integrin
  • Polyvalent interactions
  • Self-assembled monolayers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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