An inhibitor of a cell adhesion receptor stimulates cell migration

Shagufta H. Shabbir; Jessica L. Eisenberg; Milan Mrksich

doi:10.1002/anie.201002699

An inhibitor of a cell adhesion receptor stimulates cell migration

Shagufta H. Shabbir, Jessica L. Eisenberg, Milan Mrksich

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Making cells get a move on: The integrins are cell-surface receptors that mediate the adhesion and migration of cells on a protein matrix. An open question is whether addition of an inhibitor of the receptor slows or accelerates cell migration. By using self-assembled monolayers presenting a cell adhesion ligand as a model system it is found that an inhibitor (RGD peptide) can stimulate cell migration.

Original language	English (US)
Pages (from-to)	7706-7709
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	42
DOIs	https://doi.org/10.1002/anie.201002699
State	Published - Oct 11 2010

Keywords

Cell adhesion
Inhibitors
Integrin
Polyvalent interactions
Self-assembled monolayers

ASJC Scopus subject areas

General Chemistry
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201002699

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AU - Eisenberg, Jessica L.

AU - Mrksich, Milan

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AB - Making cells get a move on: The integrins are cell-surface receptors that mediate the adhesion and migration of cells on a protein matrix. An open question is whether addition of an inhibitor of the receptor slows or accelerates cell migration. By using self-assembled monolayers presenting a cell adhesion ligand as a model system it is found that an inhibitor (RGD peptide) can stimulate cell migration.

KW - Cell adhesion

KW - Inhibitors

KW - Integrin

KW - Polyvalent interactions

KW - Self-assembled monolayers

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An inhibitor of a cell adhesion receptor stimulates cell migration

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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