An Inside Job for siRNAs

Daniel E. Golden, Vincent R. Gerbasi, Erik J. Sontheimer*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

92 Scopus citations


Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.

Original languageEnglish (US)
Pages (from-to)309-312
Number of pages4
JournalMolecular cell
Issue number3
StatePublished - Aug 8 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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