An Inside Job for siRNAs

Daniel E. Golden; Vincent R. Gerbasi; Erik J. Sontheimer

doi:10.1016/j.molcel.2008.07.008

An Inside Job for siRNAs

Daniel E. Golden, Vincent R. Gerbasi, Erik J. Sontheimer^*

^*Corresponding author for this work

PCE - Proteomics Center of Excellence

Research output: Contribution to journal › Short survey › peer-review

103 Scopus citations

Abstract

Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.

Original language	English (US)
Pages (from-to)	309-312
Number of pages	4
Journal	Molecular cell
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2008.07.008
State	Published - Aug 8 2008

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2008.07.008

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title = "An Inside Job for siRNAs",

abstract = "Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.",

author = "Golden, {Daniel E.} and Gerbasi, {Vincent R.} and Sontheimer, {Erik J.}",

year = "2008",

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AU - Gerbasi, Vincent R.

AU - Sontheimer, Erik J.

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N2 - Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.

AB - Among the three main categories of small silencing RNAs in insects and mammals-siRNAs, miRNAs, and piRNAs-siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.

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JO - Molecular cell

JF - Molecular cell

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An Inside Job for siRNAs

Abstract

ASJC Scopus subject areas

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