Abstract
Facile fabrication of asymmetrically adhesive hydrogel with robust wet tissue adhesion simultaneously with effective anti-postoperative adhesion still remains a great challenge. In this work, an integrally formed Janus hydrogel is facilely fabricated in one step by controlling the interfacial distribution of free carboxyl groups on the two sides of hydrogels. At a lower stirring speed, the generated bigger sized emulsion droplets mainly occupy the top surface of hydrogel, which effectively hinders the exposition of carboxyl groups on the top surface, driving them to be more distributed on the bottom surface, ultimately resulting in the poor adhesion of top surface but robust adhesion of bottom surface to various wet tissue even underwater. The difference in adhesive strength achieves as high as 20 times between the two surfaces. In vivo rabbit experiment outcomes clearly validate that the bottom surface of hydrogel firmly adheres to the stomach defect, and the other opposite surface can efficiently address the postoperative adhesion problem. Besides, this hydrogel exhibits superior mechanical toughness and conductivity which has been used as a highly adhesive strain sensor to real-time monitor the beating heart in vivo. This simple yet effective strategy provides a much more feasible approach for creating Janus hydrogels bioadhesives.
Original language | English (US) |
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Article number | 2300394 |
Journal | Advanced Materials |
Volume | 35 |
Issue number | 23 |
DOIs | |
State | Published - Jun 8 2023 |
Funding
This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 51903093 and 32001264), the Guangdong Basic and Applied Basic Research Foundation (Grant No. 2023A1515012167), and Project of Key Disciplines of Forestry Engineering of Bureau of Education of Guangzhou Municipality. All in vivo animal surgeries and ex vivo experiments were approved by the Laboratory Animal Ethics Committee of South China Agricultural University (approval number 2021E030). And the rabbit experiments were carried out in the Animal Hospital of South China Agricultural University. The porcine skin and other tissues used were obtained from a market.
Keywords
- anti-postoperative adhesion
- asymmetric adhesion
- hydrogels
- integrally formed preparation
- robust adhesion
ASJC Scopus subject areas
- Mechanics of Materials
- Mechanical Engineering
- General Materials Science