An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children

J. Diepstraten, V. Chidambaran, S. Sadhasivam, H. J. Blusse Van Oud-Alblas, T. Inge, B. Van Ramshorst, E. P.A. Van Dongen, A. A. Vinks, C. A.J. Knibbe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

This study describes a population pharmacokinetic meta-analysis of propofol to characterize the influence of body size measures and age in morbidly obese and nonobese adults, adolescents, and children. Sixty morbidly obese and nonobese adult patients (55-167 kg; 21-79 years) and 34 morbidly obese and nonobese adolescents and children (37-184 kg; 9-20 years) were included. The results show that clearance increased with total body weight in an allometric function while age was found to influence clearance in a bilinear fashion with two distinct slopes, reflecting an initial increase and subsequent decrease as a result of aging.Using these two functions, the influence of both (over)weight and age on propofol clearance was well characterized, which may provide a basis for dosing across this diverse group of patients.

Original languageEnglish (US)
Article numbere73
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume2
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Modeling and Simulation

Fingerprint

Dive into the research topics of 'An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children'. Together they form a unique fingerprint.

Cite this