An integrative classification model for multiple sclerosis lesion detection in multimodal MRI

Fengqing (Zoe) Zhang*, Ji Ping Wang, Wenxin Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We study a classification problem of multiple sclerosis (MS) lesions in three dimensional brain magnetic resonance (MR) images. Segmentation of MS lesions is essential for MS diagnosis, assessment of disease progression and evaluation of treatment efficacy. Accurate identification of MS lesions in MR images is challenging due to variability in lesion location, size and shape in addition to anatomical variability between subjects. We propose a supervised classification algorithm for segmenting MS lesions, which integrates the intensity information from multiple MRI modalities, the texture information, and the spatial information in a Bayesian framework. A multinomial logistic regression is employed to learn the posterior probability distributions from the intensity information, combined from three MRI modalities. Texture features are selected by the Elastic Net model. The spatial information is then incorporated using a Markov random field prior. Finally, a maximum a posteriori segmentation is obtained by the graph cuts algorithm. We illustrate the effectiveness of our proposed model for lesion segmentation using both the synthetic BrainWeb data and the clinical neuroimaging data.

Original languageEnglish (US)
Pages (from-to)193-202
Number of pages10
JournalStatistics and its Interface
Issue number2
StatePublished - 2019


  • Multimodal MRI
  • Multiple sclerosis
  • Segmentation
  • Supervised classification algorithm

ASJC Scopus subject areas

  • Statistics and Probability
  • Applied Mathematics


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