An interactive learning framework for scalable classification of pathology images

Michael Nalisnik, David A. Gutman, Jun Kong, Lee Alex Donald Cooper

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Recent advances in microscopy imaging and genomics have created an explosion of patient data in the pathology domain. Whole-slide images (WSIs) of tissues can now capture disease processes as they unfold in high resolution, recording the visual cues that have been the basis of pathologic diagnosis for over a century. Each WSI contains billions of pixels and up to a million or more microanatomic objects whose appearances hold important prognostic information. Computational image analysis enables the mining of massive WSI datasets to extract quantitative morphologic features describing the visual qualities of patient tissues. When combined with genomic and clinical variables, this quantitative information provides scientists and clinicians with insights into disease biology and patient outcomes. To facilitate interaction with this rich resource, we have developed a web-based machine-learning framework that enables users to rapidly build classifiers using an intuitive active learning process that minimizes data labeling effort. In this paper we describe the architecture and design of this system, and demonstrate its effectiveness through quantification of glioma brain tumors.

Original languageEnglish (US)
Title of host publicationProceedings - 2015 IEEE International Conference on Big Data, IEEE Big Data 2015
EditorsFeng Luo, Kemafor Ogan, Mohammed J. Zaki, Laura Haas, Beng Chin Ooi, Vipin Kumar, Sudarsan Rachuri, Saumyadipta Pyne, Howard Ho, Xiaohua Hu, Shipeng Yu, Morris Hui-I Hsiao, Jian Li
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages928-935
Number of pages8
ISBN (Electronic)9781479999255
DOIs
StatePublished - Dec 22 2015
Event3rd IEEE International Conference on Big Data, IEEE Big Data 2015 - Santa Clara, United States
Duration: Oct 29 2015Nov 1 2015

Publication series

NameProceedings - 2015 IEEE International Conference on Big Data, IEEE Big Data 2015

Other

Other3rd IEEE International Conference on Big Data, IEEE Big Data 2015
CountryUnited States
CitySanta Clara
Period10/29/1511/1/15

Keywords

  • biomedical image processing
  • interactive systems
  • machine learning
  • pathology

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Science Applications
  • Information Systems
  • Software

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    Nalisnik, M., Gutman, D. A., Kong, J., & Cooper, L. A. D. (2015). An interactive learning framework for scalable classification of pathology images. In F. Luo, K. Ogan, M. J. Zaki, L. Haas, B. C. Ooi, V. Kumar, S. Rachuri, S. Pyne, H. Ho, X. Hu, S. Yu, M. H-I. Hsiao, & J. Li (Eds.), Proceedings - 2015 IEEE International Conference on Big Data, IEEE Big Data 2015 (pp. 928-935). [7363841] (Proceedings - 2015 IEEE International Conference on Big Data, IEEE Big Data 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BigData.2015.7363841