TY - JOUR
T1 - An internet-based adolescent depression preventive intervention
T2 - Study protocol for a randomized control trial
AU - Gladstone, Tracy
AU - Marko-Holguin, Monika
AU - Rothberg, Phyllis
AU - Nidetz, Jennifer
AU - Diehl, Anne
AU - DeFrino, Daniela T.
AU - Harris, Mary
AU - Ching, Eumene
AU - Eder, Milton
AU - Canel, Jason
AU - Bell, Carl
AU - Beardslee, William R.
AU - Brown, C. Hendricks
AU - Griffiths, Kathleen
AU - Van Voorhees, Benjamin W.
N1 - Funding Information:
Thanks to Rachel Lazerus who helped with conceptual planning of the website content, to Marc Kaplan for his intellectual impact regarding the website development, and Carol Tee for her recruitment and data collection at the Boston, MA study site. Special thanks to Myrna Grant for her support with clinic coordination at UIC, to Mary Harris for her management of the Boston, MA study site, and to Ruth Ross for her contribution to the initial intervention design. Research reported in this article was supported by the National Institute of Mental Health of the National Institutes of Health under award numbers K08MH072918 and R01MH090035. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Ethical bodies that approved this study include: Wellesley College Institutional Review Board (IRB), University of Illinois IRB, Advocate Health Care IRB, Franciscan St. Mary IRB, Northwestern IRB and Northshore University Healthsystem IRB.
Publisher Copyright:
© Gladstone et al.; licensee BioMed Central.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background: The high prevalence of major depressive disorder in adolescents and the low rate of successful treatment highlight a pressing need for accessible, affordable adolescent depression prevention programs. The Internet offers opportunities to provide adolescents with high quality, evidence-based programs without burdening or creating new care delivery systems. Internet-based interventions hold promise, but further research is needed to explore the efficacy of these approaches and ways of integrating emerging technologies for behavioral health into the primary care system. Methods/Design: We developed a primary care Internet-based depression prevention intervention, Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training (CATCH-IT), to evaluate a self-guided, online approach to depression prevention and are conducting a randomized clinical trial comparing CATCH-IT to a general health education Internet intervention. This article documents the research framework and randomized clinical trial design used to evaluate CATCH-IT for adolescents, in order to inform future work in Internet-based adolescent prevention programs. The rationale for this trial is introduced, the current status of the study is reviewed, and potential implications and future directions are discussed. Discussion: The current protocol represents the only current, systematic approach to connecting at-risk youth with self-directed depression prevention programs in a medical setting. This trial undertakes the complex public health task of identifying at-risk individuals through mass screening of the general primary care population, rather than solely relying on volunteers recruited over the Internet, and the trial design provides measures of both symptomatic and diagnostic clinical outcomes. At the present time, we have enrolled N=234 adolescents/expected 400 and N=186 parents/expected 400 in this trial, from N=6 major health systems. The protocol described here provides a model for a new generation of interventions that blend substantial computer-based instruction with human contact to intervene to prevent mental disorders such as depression. Because of the potential for broad generalizability of this model, the results of this study are important, as they will help develop the guidelines for preventive interventions with youth at-risk for the development of depressive and other mental disorders. Trial registration: Clinical Trial Registry: NCT01893749 date 6 May 2012.
AB - Background: The high prevalence of major depressive disorder in adolescents and the low rate of successful treatment highlight a pressing need for accessible, affordable adolescent depression prevention programs. The Internet offers opportunities to provide adolescents with high quality, evidence-based programs without burdening or creating new care delivery systems. Internet-based interventions hold promise, but further research is needed to explore the efficacy of these approaches and ways of integrating emerging technologies for behavioral health into the primary care system. Methods/Design: We developed a primary care Internet-based depression prevention intervention, Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training (CATCH-IT), to evaluate a self-guided, online approach to depression prevention and are conducting a randomized clinical trial comparing CATCH-IT to a general health education Internet intervention. This article documents the research framework and randomized clinical trial design used to evaluate CATCH-IT for adolescents, in order to inform future work in Internet-based adolescent prevention programs. The rationale for this trial is introduced, the current status of the study is reviewed, and potential implications and future directions are discussed. Discussion: The current protocol represents the only current, systematic approach to connecting at-risk youth with self-directed depression prevention programs in a medical setting. This trial undertakes the complex public health task of identifying at-risk individuals through mass screening of the general primary care population, rather than solely relying on volunteers recruited over the Internet, and the trial design provides measures of both symptomatic and diagnostic clinical outcomes. At the present time, we have enrolled N=234 adolescents/expected 400 and N=186 parents/expected 400 in this trial, from N=6 major health systems. The protocol described here provides a model for a new generation of interventions that blend substantial computer-based instruction with human contact to intervene to prevent mental disorders such as depression. Because of the potential for broad generalizability of this model, the results of this study are important, as they will help develop the guidelines for preventive interventions with youth at-risk for the development of depressive and other mental disorders. Trial registration: Clinical Trial Registry: NCT01893749 date 6 May 2012.
KW - Adolescence
KW - Adolescent depression
KW - Internet
KW - Prevention
KW - Primary care
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UR - http://www.scopus.com/inward/citedby.url?scp=84929325223&partnerID=8YFLogxK
U2 - 10.1186/s13063-015-0705-2
DO - 10.1186/s13063-015-0705-2
M3 - Article
C2 - 25927539
AN - SCOPUS:84929325223
VL - 16
JO - Trials
JF - Trials
SN - 1745-6215
IS - 1
M1 - 203
ER -