TY - JOUR
T1 - An investigation of candidate regions for association with bipolar disorder
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - NIMH Genetics Initiative Bipolar Disorder Consortium
AU - Knight, Jo
AU - Rochberg, Nanette S.
AU - Saccone, Scott F.
AU - Nurnberger, John I.
AU - Rice, John P.
AU - Nurnberger, John
AU - Miller, Marvin J.
AU - Bowman, Elizabeth S.
AU - Rau, N. Leela
AU - Moe, P. Ryan
AU - Samavedy, Nalini
AU - El-Mallakh, Rif
AU - Manji, Husseini
AU - Glitz, Debra A.
AU - Meyer, Eric T.
AU - Smiley, Carrie
AU - Foroud, Tatiana
AU - Flury, Leah
AU - Dick, Danielle M.
AU - Edenberg, Howard
AU - Reich, Theodore
AU - Goate, Allison
AU - Bierut, Laura
AU - McInnis, Melvin
AU - DePaulo, J. Raymond
AU - MacKinnon, Dean F.
AU - Mondimore, Francis M.
AU - Potash, James B.
AU - Zandi, Peter P.
AU - Avramopoulos, Dimitrios
AU - Payne, Jennifer
AU - Berrettini, Wade
AU - Byerley, William
AU - Vinogradov, Sophia
AU - Coryell, William
AU - Crowe, Raymond
AU - Gershon, Elliot
AU - Badner, Judith
AU - McMahon, Francis
AU - Liu, Chunyu
AU - Sanders, Alan
AU - Caserta, Maria
AU - Dinwiddie, Steven
AU - Nguyen, Tu
AU - Harakal, Donna
AU - Kelsoe, John
AU - McKinney, Rebecca
AU - Scheftner, William
AU - Kravitz, Howard M.
AU - Marta, Diana
N1 - Publisher Copyright:
© 2010 Wiley-Liss, Inc.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2×10-5). Both P-values are in the top 5% of the distribution derived from null simulations (P=0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.
AB - We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2×10-5). Both P-values are in the top 5% of the distribution derived from null simulations (P=0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.
KW - Association
KW - Bipolar disorder
KW - Genetics
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UR - http://www.scopus.com/inward/citedby.url?scp=77957362852&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.31100
DO - 10.1002/ajmg.b.31100
M3 - Article
C2 - 20872768
AN - SCOPUS:77957362852
SN - 1552-4841
VL - 153
SP - 1292
EP - 1297
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 7
ER -
