TY - JOUR
T1 - An offset ON–OFF receptive field is created by gap junctions between distinct types of retinal ganglion cells
AU - Cooler, Sam
AU - Schwartz, Gregory W.
N1 - Funding Information:
We thank the entire Schwartz Laboratory group for discussions, advice and support. We thank B. Novich for generously providing the FOXP1 antibody. Imaging work was performed at the Northwestern University Center for Advanced Microscopy, generously supported by a National Cancer Institute cancer center support grant (P30 CA060553) awarded to the Robert H. Lurie Comprehensive Cancer Center. Multiphoton microscopy was performed on a Nikon A1R multiphoton microscope, acquired through the support of the National Institutes of Health (NIH; 1S10OD010398-01). This work was supported by grants from the NIH National Eye Institute (F31 EY029593 and T32 EY025202) and an NIH Director’s New Innovator (DP2) award (EY026770).
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/1
Y1 - 2021/1
N2 - In the vertebrate retina, the location of a neuron’s receptive field in visual space closely corresponds to the physical location of synaptic input onto its dendrites, a relationship called the retinotopic map. We report the discovery of a systematic spatial offset between the ON and OFF receptive subfields in F-mini-ON retinal ganglion cells (RGCs). Surprisingly, this property does not come from spatially offset ON and OFF layer dendrites, but instead arises from a network of electrical synapses via gap junctions to RGCs of a different type, the F-mini-OFF. We show that the asymmetric morphology and connectivity of these RGCs can explain their receptive field offset, and we use a multicell model to explore the effects of receptive field offset on the precision of edge-location representation in a population. This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways within the output layer of the retina.
AB - In the vertebrate retina, the location of a neuron’s receptive field in visual space closely corresponds to the physical location of synaptic input onto its dendrites, a relationship called the retinotopic map. We report the discovery of a systematic spatial offset between the ON and OFF receptive subfields in F-mini-ON retinal ganglion cells (RGCs). Surprisingly, this property does not come from spatially offset ON and OFF layer dendrites, but instead arises from a network of electrical synapses via gap junctions to RGCs of a different type, the F-mini-OFF. We show that the asymmetric morphology and connectivity of these RGCs can explain their receptive field offset, and we use a multicell model to explore the effects of receptive field offset on the precision of edge-location representation in a population. This RGC network forms a new electrical channel combining the ON and OFF feedforward pathways within the output layer of the retina.
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U2 - 10.1038/s41593-020-00747-8
DO - 10.1038/s41593-020-00747-8
M3 - Article
C2 - 33230322
AN - SCOPUS:85096447089
SN - 1097-6256
VL - 24
SP - 105
EP - 115
JO - Nature neuroscience
JF - Nature neuroscience
IS - 1
ER -