An olfactory subsystem that mediates high-sensitivity detection of volatile amines

Rodrigo Pacifico, Adam Dewan, Dillon Cawley, Caiying Guo, Thomas Bozza*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Olfactory stimuli are detected by over 1,000 odorant receptors in mice, with each receptor being mapped to specific glomeruli in the olfactory bulb. The trace amine-associated receptors (TAARs) are a small family of evolutionarily conserved olfactory receptors whose contribution to olfaction remains enigmatic. Here, we show that a majority of the TAARs are mapped to a discrete subset of glomeruli in the dorsal olfactory bulb of the mouse. This TAAR projection is distinct from the previously described class I and class II domains, and is formed by a sensory neuron population that is restricted to express TAAR genes prior to choice. We also show that the dorsal TAAR glomeruli are selectively activated by amines at low concentrations. Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines.

Original languageEnglish (US)
Pages (from-to)76-88
Number of pages13
JournalCell reports
Volume2
Issue number1
DOIs
StatePublished - Jul 26 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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