@article{9a0f5f429d1842029fba270be2419ff8,
title = "An olfactory subsystem that mediates high-sensitivity detection of volatile amines",
abstract = "Olfactory stimuli are detected by over 1,000 odorant receptors in mice, with each receptor being mapped to specific glomeruli in the olfactory bulb. The trace amine-associated receptors (TAARs) are a small family of evolutionarily conserved olfactory receptors whose contribution to olfaction remains enigmatic. Here, we show that a majority of the TAARs are mapped to a discrete subset of glomeruli in the dorsal olfactory bulb of the mouse. This TAAR projection is distinct from the previously described class I and class II domains, and is formed by a sensory neuron population that is restricted to express TAAR genes prior to choice. We also show that the dorsal TAAR glomeruli are selectively activated by amines at low concentrations. Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines.",
author = "Rodrigo Pacifico and Adam Dewan and Dillon Cawley and Caiying Guo and Thomas Bozza",
note = "Funding Information: This work was supported by grants from the NIH/NIDCD and by the Visiting Scientist Program at Janelia Farm Research Campus. We thank Paul Feinstein for scientific discussions, for assistance in generating mouse strains, and for comments on the manuscript; Ivan Rodriguez for comments on the manuscript; Dmitry Rinberg for help with olfactometry and scientific discussions; Matt Wachowiak for advice on bulb imaging and for comments on an earlier version of the manuscript; Chingwen Yang and Rada Norinsky and the Gene Targeting and Transgenic Resource Centers at Rockefeller University and Lynn Doglio and the Transgenic and Targeted Mutagenesis Lab at Northwestern University for assistance with gene targeting; and Jim Cox and the staff at Janelia Farm for mouse colony maintenance. Thanks to Brian Weiland and Stephanie Leung for technical assistance. We also thank Ann Palmenberg and Georg Nagel for providing IRES and ChYFP constructs, and Walter Tsark for HPRT-Cre mice. ",
year = "2012",
month = jul,
day = "26",
doi = "10.1016/j.celrep.2012.06.006",
language = "English (US)",
volume = "2",
pages = "76--88",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}