Abstract
Store-operated Orai channels are a primary mechanism for mobilizing Ca2+ signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation.
Original language | English (US) |
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Article number | 102366 |
Journal | Cell Calcium |
Volume | 94 |
DOIs |
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State | Published - Mar 2021 |
Funding
This work was support by National Institites of Health grant R01 NS057499 .
Keywords
- Calcium selectivity
- Ion channel
- Ion channel gating
- Orai
- Orai1
- STIM1
- Structure
ASJC Scopus subject areas
- Molecular Biology
- Physiology
- Cell Biology