An open pore structure of the Orai channel, finally

Murali Prakriya*, Priscilla See Wai Yeung, Megumi Yamashita

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations


Store-operated Orai channels are a primary mechanism for mobilizing Ca2+ signals in both non-excitable cells and excitable cells. The structure of the open channel, vital for understanding the mechanism of channel opening, is incompletely understood. We highlight a new study that unveils the structure of a constitutively active Orai mutant and takes us closer towards understanding the molecular basis of Orai channel activation.

Original languageEnglish (US)
Article number102366
JournalCell Calcium
StatePublished - Mar 2021


  • Calcium selectivity
  • Ion channel
  • Ion channel gating
  • Orai
  • Orai1
  • STIM1
  • Structure

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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