An overview of meningiomas

Robin A. Buerki, Craig M. Horbinski, Timothy Kruser, Peleg M. Horowitz, Charles David James, Rimas V. Lukas*

*Corresponding author for this work

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Meningiomas are the most common primary intracranial tumor. Important advances are occurring in meningioma research. These are expected to accelerate, potentially leading to impactful changes on the management of meningiomas in the near and medium term. This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors. We will discuss clinical and radiographic presentation and therapeutic management. Surgery and radiotherapy, the two longstanding primary therapeutic modalities, will be discussed at length. In addition, data from prior and ongoing investigations of other treatment modalities, including systemic and targeted therapies, will be covered. This review will quickly update the reader on the contemporary management and future directions in meningiomas. </inline-graphic.

Original languageEnglish (US)
Pages (from-to)2161-2177
Number of pages17
JournalFuture Oncology
Volume14
Issue number21
DOIs
StatePublished - Sep 2018

Keywords

  • chemotherapy
  • imaging
  • meningioma
  • molecular pathology
  • mutations
  • radiotherapy
  • stereotactic radiosurgery
  • surgery
  • targeted therapy
  • tumor treating fields

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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