An update on current treatment strategies for laryngopharyngeal reflux symptoms

Amanda J. Krause, Erin H. Walsh, Philip A. Weissbrod, Tiffany H. Taft, Rena Yadlapati*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Laryngopharyngeal reflux (LPR) is a syndrome caused by reflux of gastric contents into the pharynx or larynx, which leads to symptoms of throat clearing, hoarseness, pain, globus sensation, cough, excess mucus production in the throat, and dysphonia. LPR is a challenging condition, as there is currently no gold standard for diagnosis or treatment, and thus this presents a burden to the healthcare system. Strategies for treatment of LPR are numerous. Medical therapies include proton pump inhibitors, which are first line, H2 receptor antagonists, alginates, and baclofen. Other noninvasive treatment options include lifestyle therapy and the external upper esophageal sphincter compression device. Endoscopic and surgical options include antireflux surgery, magnetic sphincter augmentation, and transoral incisionless fundoplication. Functional laryngeal disorders and laryngeal hypersensitivity can present as LPR symptoms with or without gastroesophageal reflux disease. Though there are minimal studies in this area, neuromodulators and behavioral interventions are potential treatment options. Given the complexity of these patients and numerous available treatment options, we propose a treatment algorithm to help clinicians diagnose and triage patients into an appropriate therapy.

Original languageEnglish (US)
Pages (from-to)5-17
Number of pages13
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Apr 2022


  • extraesophageal reflux
  • gastroesophageal reflux
  • laryngopharyngeal reflux
  • treatment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • History and Philosophy of Science


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