An update on donor-derived disease transmission in organ transplantation

M. G. Ison, M. A. Nalesnik

Research output: Contribution to journalReview articlepeer-review

152 Scopus citations

Abstract

Several recent donor-to-recipient disease transmissions have highlighted the importance of this rare complication of solid organ transplantation. The epidemiology of donor-derived disease transmissions in the United States has been described through reports to the Organ Procurement and Transplant Network (OPTN); these reports are reviewed and categorized by the ad hoc Disease Transmission Advisory Committee (DTAC); additional data comes through the published literature. From these reports, it is possible to estimate that donor-derived disease transmission complicates less than 1% of all transplant procedures but when a transmission occurs, significant morbidity and mortality can result. Only through continued presentation of the available data can continuous quality improvements be made. As the epidemiology of donor-derived disease transmission has become better understood, several groups have been working on methods to further mitigate this risk. The authors review the current epidemiology of donor-derived diseases and outline key next steps.

Original languageEnglish (US)
Pages (from-to)1123-1130
Number of pages8
JournalAmerican Journal of Transplantation
Volume11
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Donor-derived
  • donor screening
  • infection
  • malignancy
  • patient safety
  • transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'An update on donor-derived disease transmission in organ transplantation'. Together they form a unique fingerprint.

Cite this