Abstract
Several recent donor-to-recipient disease transmissions have highlighted the importance of this rare complication of solid organ transplantation. The epidemiology of donor-derived disease transmissions in the United States has been described through reports to the Organ Procurement and Transplant Network (OPTN); these reports are reviewed and categorized by the ad hoc Disease Transmission Advisory Committee (DTAC); additional data comes through the published literature. From these reports, it is possible to estimate that donor-derived disease transmission complicates less than 1% of all transplant procedures but when a transmission occurs, significant morbidity and mortality can result. Only through continued presentation of the available data can continuous quality improvements be made. As the epidemiology of donor-derived disease transmission has become better understood, several groups have been working on methods to further mitigate this risk. The authors review the current epidemiology of donor-derived diseases and outline key next steps.
Original language | English (US) |
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Pages (from-to) | 1123-1130 |
Number of pages | 8 |
Journal | American Journal of Transplantation |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2011 |
Keywords
- Donor-derived
- donor screening
- infection
- malignancy
- patient safety
- transplantation
ASJC Scopus subject areas
- Immunology and Allergy
- Transplantation
- Pharmacology (medical)