An update on fluid resuscitation

Hasan B. Alam*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Hemorrhagic shock is the leading cause of death in civilian and military trauma. Effective hemorrhage control and better resuscitation strategies have the potential of saving lives. However, if not performed properly, resuscitation can actually exacerbate cellular injury caused by hemorrhagic shock, and the type of fluid used for resuscitation plays an important role in this injury pattern. It is logical to prevent this cellular injury through wiser resuscitation strategies than attempting immunomodulation after the damage has already occurred. It is important to recognize that unlike numerous other variables, resuscitation is completely under our control. We decide who, when and how should get resuscitated. This paper summarizes data from a number of studies to illustrate the differential effects of commonly used resuscitation fluids on cellular injury, and how these relate to clinical practice. In addition, some novel resuscitation strategies are described that may become clinically available in the near future.

Original languageEnglish (US)
Pages (from-to)136-145
Number of pages10
JournalScandinavian Journal of Surgery
Volume95
Issue number3
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • Apoptosis
  • Blood
  • Cellular injury
  • Fluids
  • Gene transcription
  • Hypertonic saline
  • Hypothermia
  • Immune activation
  • Inflammation
  • Plasma
  • Resuscitation
  • Shock

ASJC Scopus subject areas

  • Surgery

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