TY - JOUR
T1 - An update on PYRIN domain-containing pattern recognition receptors
T2 - From immunity to pathology
AU - Ratsimandresy, Rojo A.
AU - Dorfleutner, Andrea
AU - Stehlik, Christian
PY - 2013
Y1 - 2013
N2 - Cytosolic pattern recognition receptors (PRRs) sense a wide range of endogenous danger-associated molecular patterns as well as exogenous pathogen-associated molecular patterns. In particular, Nod-like receptors containing a pyrin domain (PYD), called NLRPs, and AIM2-like receptors (ALRs) have been shown to play a critical role in host defense by facilitating clearance of pathogens and maintaining a healthy gut microflora. NLRPs and ALRs both encode a PYD, which is crucial for relaying signals that result in an efficient innate immune response through activation of several key innate immune signaling pathways. However, mutations in these PRRs have been linked to the development of auto-inflammatory and autoimmune diseases. In addition, they have been implicated in metabolic diseases. In this review, we summarize the function of PYD-containing NLRPs and ALRs and address their contribution to innate immunity, host defense, and immune-linked diseases.
AB - Cytosolic pattern recognition receptors (PRRs) sense a wide range of endogenous danger-associated molecular patterns as well as exogenous pathogen-associated molecular patterns. In particular, Nod-like receptors containing a pyrin domain (PYD), called NLRPs, and AIM2-like receptors (ALRs) have been shown to play a critical role in host defense by facilitating clearance of pathogens and maintaining a healthy gut microflora. NLRPs and ALRs both encode a PYD, which is crucial for relaying signals that result in an efficient innate immune response through activation of several key innate immune signaling pathways. However, mutations in these PRRs have been linked to the development of auto-inflammatory and autoimmune diseases. In addition, they have been implicated in metabolic diseases. In this review, we summarize the function of PYD-containing NLRPs and ALRs and address their contribution to innate immunity, host defense, and immune-linked diseases.
KW - AIM2-like receptor
KW - ALR
KW - Inflammasome
KW - Innate immunity
KW - NLR
KW - Nod-like receptor
KW - PYRIN domain
KW - Pattern recognition receptor
UR - http://www.scopus.com/inward/record.url?scp=84892149853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892149853&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2013.00440
DO - 10.3389/fimmu.2013.00440
M3 - Review article
C2 - 24367371
AN - SCOPUS:84892149853
VL - 4
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - DEC
M1 - Article 440
ER -