An update on PYRIN domain-containing pattern recognition receptors: From immunity to pathology

Rojo A. Ratsimandresy, Andrea Dorfleutner, Christian Stehlik*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Cytosolic pattern recognition receptors (PRRs) sense a wide range of endogenous danger-associated molecular patterns as well as exogenous pathogen-associated molecular patterns. In particular, Nod-like receptors containing a pyrin domain (PYD), called NLRPs, and AIM2-like receptors (ALRs) have been shown to play a critical role in host defense by facilitating clearance of pathogens and maintaining a healthy gut microflora. NLRPs and ALRs both encode a PYD, which is crucial for relaying signals that result in an efficient innate immune response through activation of several key innate immune signaling pathways. However, mutations in these PRRs have been linked to the development of auto-inflammatory and autoimmune diseases. In addition, they have been implicated in metabolic diseases. In this review, we summarize the function of PYD-containing NLRPs and ALRs and address their contribution to innate immunity, host defense, and immune-linked diseases.

Original languageEnglish (US)
Article numberArticle 440
JournalFrontiers in immunology
Volume4
Issue numberDEC
DOIs
StatePublished - 2013

Keywords

  • AIM2-like receptor
  • ALR
  • Inflammasome
  • Innate immunity
  • NLR
  • Nod-like receptor
  • PYRIN domain
  • Pattern recognition receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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