An updated view on the structure and function of PYRIN domains

Lan Hoang Chu, Anu Gangopadhyay, Andrea Dorfleutner*, Christian Stehlik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The PYRIN domain (PYD) is a protein-protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling function in innate immune responses and particularly in the assembly of inflammasomes, which are large protein complexes that allow the induced proximity-mediated activation of caspase-1 and subsequently the release of pro-inflammatory cytokines. The molecular mechanism of inflammasome assembly was only recently elucidated and specifically requires PYD oligomerization. Here we discuss the recent advances in our understanding of PYD signaling and its regulation by PYD-only proteins.

Original languageEnglish (US)
Pages (from-to)157-173
Number of pages17
JournalApoptosis
Volume20
Issue number2
DOIs
StatePublished - Feb 2015

Keywords

  • AIM2-like receptor (ALR)
  • Inflammasome
  • Inflammation
  • Nod-like receptor (NLR)
  • PYRIN domain (PYD)
  • PYRIN domain-only protein (POP)

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Cancer Research

Fingerprint

Dive into the research topics of 'An updated view on the structure and function of PYRIN domains'. Together they form a unique fingerprint.

Cite this