An upward shift of intracellular pH rather than the final absolute pH value is critical for controlling gap junction permeability in tumor promoter-treated cells

Irina Budunova, Leonid A. Mittelman, Leonid B. Margolis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The tumor promoter TPA is found to inhibit gap junction permeability in monolayer cultures of hamster fibroblasts. This effect is associated with an increase in intracellular pH. Here we show that neither an increase in pH1 alone nor TPA treatment under conditions preventing pH1-shift affect gap junction permeability. It is not the level of pH1 reached, but rather the pH1-shift itself that is essential for the inhibition of gap junction permeability in the presence of TPA.

Original languageEnglish (US)
Pages (from-to)52-54
Number of pages3
JournalFEBS Letters
Volume279
Issue number1
DOIs
StatePublished - Feb 11 1991

Keywords

  • Cell-cell communication
  • Intracellular pH

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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