An upward shift of intracellular pH rather than the final absolute pH value is critical for controlling gap junction permeability in tumor promoter-treated cells

Irina Budunova; Leonid A. Mittelman; Leonid B. Margolis

doi:10.1016/0014-5793(91)80248-2

An upward shift of intracellular pH rather than the final absolute pH value is critical for controlling gap junction permeability in tumor promoter-treated cells

Irina Budunova, Leonid A. Mittelman, Leonid B. Margolis^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The tumor promoter TPA is found to inhibit gap junction permeability in monolayer cultures of hamster fibroblasts. This effect is associated with an increase in intracellular pH. Here we show that neither an increase in pH₁ alone nor TPA treatment under conditions preventing pH₁-shift affect gap junction permeability. It is not the level of pH₁ reached, but rather the pH₁-shift itself that is essential for the inhibition of gap junction permeability in the presence of TPA.

Original language	English (US)
Pages (from-to)	52-54
Number of pages	3
Journal	FEBS Letters
Volume	279
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(91)80248-2
State	Published - Feb 11 1991

Keywords

Cell-cell communication
Intracellular pH

ASJC Scopus subject areas

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

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10.1016/0014-5793(91)80248-2

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abstract = "The tumor promoter TPA is found to inhibit gap junction permeability in monolayer cultures of hamster fibroblasts. This effect is associated with an increase in intracellular pH. Here we show that neither an increase in pH1 alone nor TPA treatment under conditions preventing pH1-shift affect gap junction permeability. It is not the level of pH1 reached, but rather the pH1-shift itself that is essential for the inhibition of gap junction permeability in the presence of TPA.",

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AU - Budunova, Irina

AU - Mittelman, Leonid A.

AU - Margolis, Leonid B.

PY - 1991/2/11

Y1 - 1991/2/11

N2 - The tumor promoter TPA is found to inhibit gap junction permeability in monolayer cultures of hamster fibroblasts. This effect is associated with an increase in intracellular pH. Here we show that neither an increase in pH1 alone nor TPA treatment under conditions preventing pH1-shift affect gap junction permeability. It is not the level of pH1 reached, but rather the pH1-shift itself that is essential for the inhibition of gap junction permeability in the presence of TPA.

AB - The tumor promoter TPA is found to inhibit gap junction permeability in monolayer cultures of hamster fibroblasts. This effect is associated with an increase in intracellular pH. Here we show that neither an increase in pH1 alone nor TPA treatment under conditions preventing pH1-shift affect gap junction permeability. It is not the level of pH1 reached, but rather the pH1-shift itself that is essential for the inhibition of gap junction permeability in the presence of TPA.

KW - Cell-cell communication

KW - Intracellular pH

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JF - FEBS Letters

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An upward shift of intracellular pH rather than the final absolute pH value is critical for controlling gap junction permeability in tumor promoter-treated cells

Abstract

Keywords

ASJC Scopus subject areas

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