Analgesia for orofacial nociception produced by morphine microinjection into the spinal trigeminal complex 1

Joel P Rosenfeld*, Catherine Pickrel, James G. Broton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Morphine sulfate (0.75 μg) was microinjected into (rat) rostral and caudal trigeminal areas singly and simultaneously, using cannula-electrode combinations. Also, 0.5 μg or 1.0 μg of morphine was injected into nucleus reticularis paragi-gantocellularis (PGC). Both single trigeminal nuclear microinjections significantly elevated the latency to a defensive face-rub reaction to noxious facial heat, bilaterally. There was no summation effect with the conjoint injection of 1.5 μg total to rostral and caudal nuclear areas. The 0.5 μg injection in PGC had a significantly larger effect than did the 0.75 μg trigeminal injections. The caudal but not the rostral trigeminal injections did elevate the threshold for aversive reaction to caudal trigeminal nuclear stimulation of the injected tissue. This finding contrasts with the previously reported fact that as much as 1.0 μg of morphine in PGC has no effect on this aversive reaction threshold to brain stimulation.

Original languageEnglish (US)
Pages (from-to)145-155
Number of pages11
JournalPain
Volume15
Issue number1-4
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neurology
  • Pharmacology
  • Clinical Psychology

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