Analysis of complete responders after initial treatment with chemotherapy in head and neck cancer

M. S. Kies, Leo I Gordon, W. W. Hauck, Y. Krespi, R. H. Ossoff, B. C. Pecaro, C. Yuska, C. H. Lamut, W. N. Brand, S. K. Chang

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

We treated 60 patients with cisplatin-based combination chemotherapy before definitive surgery and/or radiation. All had squamous cell tumors of the head and neck, stages II to IV, M 0 . Twelve patients (20%) achieved a complete remission after chemotherapy. Eight of these patients showed no histologic evidence of residual disease after biopsy or surgery. Definitive local therapy with surgery and/or radiation was carried out on almost all patients regardless of the extent of the response to preceding chemotherapy. Chemotherapy-induced complete responders have had an improved survival rate in comparison with patients achieving a partial response or less. The extent of primary tumor correlates inversely with a complete response to chemotherapy.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume93
Issue number2
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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