Analysis of complex cardiovascular flow with three-component acceleration-encoded MRI

Alex J. Barker*, Felix Staehle, Jelena Bock, Bernd A. Jung, Michael Markl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Functional information regarding cardiac performance, pressure gradients, and local flow derangement are available from blood acceleration fields. Thus, this study examines a 2D and 3D phase contrast sequence optimized to efficiently encode three-directional, time-resolved acceleration in vitro and in vivo. Stenosis phantom acceleration measurements were compared to acceleration derived from standard velocity encoded phase contrast-magnetic resonance imaging (i.e., "velocity-derived acceleration"). For in vivo analysis, three-directional 2D acceleration maps were compared to velocity-derived acceleration using regions proximal and distal to the aortic valve in six healthy volunteers at 1.5 and 3.0 T (voxel size = 1.4 × 2.1 × 8 mm, temporal resolution = 16-20 ms). In addition, a 4D acceleration sequence was evaluated for feasibility in a healthy volunteer and postrepair biscuspid aortic valve patient with an ascending aortic aneurysm. The phantom magnetic resonance acceleration measurements were more accurate (nonturbulent root mean square error = 2.2 vs. 5.1 m/s2 for phase contrast-magnetic resonance imaging) and 10 times less noisy (nonturbulent σ = 0.9 vs. 13.6 m/s 2 for phase contrast-magnetic resonance imaging) than velocity-derived acceleration. Acceleration mapping of the left ventricular outflow tract and aortic arch exhibited signal voids colocated with complex flow events such as vortex formation and high order motion. 4D acceleration data, visualized in combination with the velocity data, may provide new insight into complex flow phenomena.

Original languageEnglish (US)
Pages (from-to)50-61
Number of pages12
JournalMagnetic resonance in medicine
Issue number1
StatePublished - Jan 2012


  • acceleration-encoding
  • aortic aneurysm
  • intravoxel dephasing
  • phase-contrast magnetic resonance imaging
  • stenosis
  • turbulence
  • velocity-encoding

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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