Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas

Cargill H. Alleyne; Ju He; Jing Yang; Stephen B. Hunter; George Cotsonis; C. David James; Jeffrey J. Olson

doi:10.3892/ijo.14.6.1111

Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas

Cargill H. Alleyne, Ju He, Jing Yang, Stephen B. Hunter, George Cotsonis, C. David James, Jeffrey J. Olson^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

Original language	English (US)
Pages (from-to)	1111-1116
Number of pages	6
Journal	International journal of oncology
Volume	14
Issue number	6
DOIs	https://doi.org/10.3892/ijo.14.6.1111
State	Published - Jun 1999

Keywords

Brain neoplasm
Cyclin-dependent kinase inhibitor
Malignant astrocytoma
p16
p21
p27

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ijo.14.6.1111

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title = "Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas",

abstract = "The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.",

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T1 - Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas

AU - Alleyne, Cargill H.

AU - He, Ju

AU - Yang, Jing

AU - Hunter, Stephen B.

AU - Cotsonis, George

AU - James, C. David

AU - Olson, Jeffrey J.

PY - 1999/6

Y1 - 1999/6

N2 - The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

AB - The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

KW - Brain neoplasm

KW - Cyclin-dependent kinase inhibitor

KW - Malignant astrocytoma

KW - p16

KW - p21

KW - p27

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Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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