Analysis of mast cell function in biological responses not involving IgE

S. J. Galli, B. K. Wershil, Y. A. Mekori

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Mast cells are critical for the expression of certain IgE-mediated responses, but the precise contributions of mast cells to biological processes not involving IgE are obscure. We have employed genetically mast cell-deficient WBB6F1-W/W(v) and WCB6F1-Sl/Sl(d) mice to investigate the roles of mast cells in several different biological responses. This work strongly suggests that mast cells are not required for the elicitation of contact sensitivity (CS) responses, suppressor T cell-dependent tolerance to CS, reserpine-induced inhibition of CS responses, or bleomycin-induced pulmonary fibrosis. By contrast, mast cells appear to contribute to the acute gastric injury induced by ethanol and the acute inflammation of the skin induced by croton oil.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalInternational Archives of Allergy and Applied Immunology
Volume82
Issue number3-4
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy

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