Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients

C. S. Goldstein; J. S. Bomalaski; R. B. Zurier; E. G. Neilson; S. D. Douglas

doi:10.1038/ki.1984.209

Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients

C. S. Goldstein, J. S. Bomalaski, R. B. Zurier, E. G. Neilson, S. D. Douglas

Dean's Office

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Peritoneal macrophages (PMC) from patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were compared to peritoneal macrophages from healthy volunteers and to peritoneal blood monocytes (PBM) from CAPD patients, hemodialysis patients, and healthy volunteers. PMC from CAPD patients had morphology similar to PMC and PBM from healthy volunteers. HLA-DR antigen and Fc receptors were present on the cell surface. These monocytes had similar sequential morphologic changes in long-term culture compared to PBM from healthy volunteers. Phagocytosis, hydrogen peroxide generation and bactericidal activity were the same in PMC from CAPD patients as in PBM from healthy volunteers. Chemotaxis and eicosanoid precursor uptake studies suggest that PMC from CAPD patients may be relatively immature bone-marrow-derived cells. Although these cells function well as phagocytes, further study is warranted to define their immune competence, many components of which develop during differentiation into mature macrophages and may therefore be deficient in patients undergoing CAPD.

Original language	English (US)
Pages (from-to)	733-740
Number of pages	8
Journal	Kidney international
Volume	26
Issue number	5
DOIs	https://doi.org/10.1038/ki.1984.209
State	Published - 1984

Funding

This paper has been presented in part at the 16th Annual Meeting of the American Society of Nephrology, Washington, D.C., December 6. 1983. This work was supported in part by National Institutes of Health grants 5T32 AM 07006, 5T32 AM 07442, AM-28560, AM-30280, HL 27068, NS 17752, and grants from the National Kidney Foundation, the Arthritis Foundation, and the Thrasher Research Fund. E. G. Neilson is the recipient of a Clinician-Scientist Award (80-411) from the Ameri- can Heart Association and its Pennsylvania Affiliates. The authors thank Ms. A. Buchan and Ms. C. Moffitt for technical assistance and Dr. S. Sondheimer of the Division of Reproductive Endocrinology in the Department of Obstetrics and Gynecology at the University of Pennsylvania, for enthusiastic support and participation.

ASJC Scopus subject areas

Nephrology

Access to Document

10.1038/ki.1984.209

Cite this

@article{bda5c5be666141469cb88bf4a9b94087,

title = "Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients",

abstract = "Peritoneal macrophages (PMC) from patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were compared to peritoneal macrophages from healthy volunteers and to peritoneal blood monocytes (PBM) from CAPD patients, hemodialysis patients, and healthy volunteers. PMC from CAPD patients had morphology similar to PMC and PBM from healthy volunteers. HLA-DR antigen and Fc receptors were present on the cell surface. These monocytes had similar sequential morphologic changes in long-term culture compared to PBM from healthy volunteers. Phagocytosis, hydrogen peroxide generation and bactericidal activity were the same in PMC from CAPD patients as in PBM from healthy volunteers. Chemotaxis and eicosanoid precursor uptake studies suggest that PMC from CAPD patients may be relatively immature bone-marrow-derived cells. Although these cells function well as phagocytes, further study is warranted to define their immune competence, many components of which develop during differentiation into mature macrophages and may therefore be deficient in patients undergoing CAPD.",

author = "Goldstein, {C. S.} and Bomalaski, {J. S.} and Zurier, {R. B.} and Neilson, {E. G.} and Douglas, {S. D.}",

note = "Funding Information: This paper has been presented in part at the 16th Annual Meeting of the American Society of Nephrology, Washington, D.C., December 6. 1983. This work was supported in part by National Institutes of Health grants 5T32 AM 07006, 5T32 AM 07442, AM-28560, AM-30280, HL 27068, NS 17752, and grants from the National Kidney Foundation, the Arthritis Foundation, and the Thrasher Research Fund. E. G. Neilson is the recipient of a Clinician-Scientist Award (80-411) from the Ameri- can Heart Association and its Pennsylvania Affiliates. The authors thank Ms. A. Buchan and Ms. C. Moffitt for technical assistance and Dr. S. Sondheimer of the Division of Reproductive Endocrinology in the Department of Obstetrics and Gynecology at the University of Pennsylvania, for enthusiastic support and participation.",

year = "1984",

doi = "10.1038/ki.1984.209",

language = "English (US)",

volume = "26",

pages = "733--740",

journal = "Kidney international",

issn = "0085-2538",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients

AU - Goldstein, C. S.

AU - Bomalaski, J. S.

AU - Zurier, R. B.

AU - Neilson, E. G.

AU - Douglas, S. D.

N1 - Funding Information: This paper has been presented in part at the 16th Annual Meeting of the American Society of Nephrology, Washington, D.C., December 6. 1983. This work was supported in part by National Institutes of Health grants 5T32 AM 07006, 5T32 AM 07442, AM-28560, AM-30280, HL 27068, NS 17752, and grants from the National Kidney Foundation, the Arthritis Foundation, and the Thrasher Research Fund. E. G. Neilson is the recipient of a Clinician-Scientist Award (80-411) from the Ameri- can Heart Association and its Pennsylvania Affiliates. The authors thank Ms. A. Buchan and Ms. C. Moffitt for technical assistance and Dr. S. Sondheimer of the Division of Reproductive Endocrinology in the Department of Obstetrics and Gynecology at the University of Pennsylvania, for enthusiastic support and participation.

PY - 1984

Y1 - 1984

N2 - Peritoneal macrophages (PMC) from patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were compared to peritoneal macrophages from healthy volunteers and to peritoneal blood monocytes (PBM) from CAPD patients, hemodialysis patients, and healthy volunteers. PMC from CAPD patients had morphology similar to PMC and PBM from healthy volunteers. HLA-DR antigen and Fc receptors were present on the cell surface. These monocytes had similar sequential morphologic changes in long-term culture compared to PBM from healthy volunteers. Phagocytosis, hydrogen peroxide generation and bactericidal activity were the same in PMC from CAPD patients as in PBM from healthy volunteers. Chemotaxis and eicosanoid precursor uptake studies suggest that PMC from CAPD patients may be relatively immature bone-marrow-derived cells. Although these cells function well as phagocytes, further study is warranted to define their immune competence, many components of which develop during differentiation into mature macrophages and may therefore be deficient in patients undergoing CAPD.

AB - Peritoneal macrophages (PMC) from patients undergoing continuous ambulatory peritoneal dialysis (CAPD) were compared to peritoneal macrophages from healthy volunteers and to peritoneal blood monocytes (PBM) from CAPD patients, hemodialysis patients, and healthy volunteers. PMC from CAPD patients had morphology similar to PMC and PBM from healthy volunteers. HLA-DR antigen and Fc receptors were present on the cell surface. These monocytes had similar sequential morphologic changes in long-term culture compared to PBM from healthy volunteers. Phagocytosis, hydrogen peroxide generation and bactericidal activity were the same in PMC from CAPD patients as in PBM from healthy volunteers. Chemotaxis and eicosanoid precursor uptake studies suggest that PMC from CAPD patients may be relatively immature bone-marrow-derived cells. Although these cells function well as phagocytes, further study is warranted to define their immune competence, many components of which develop during differentiation into mature macrophages and may therefore be deficient in patients undergoing CAPD.

UR - http://www.scopus.com/inward/record.url?scp=0021748306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021748306&partnerID=8YFLogxK

U2 - 10.1038/ki.1984.209

DO - 10.1038/ki.1984.209

M3 - Article

C2 - 6596459

AN - SCOPUS:0021748306

SN - 0085-2538

VL - 26

SP - 733

EP - 740

JO - Kidney international

JF - Kidney international

IS - 5

ER -

Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this