Analysis of tau haplotypes in Pick's disease

H. R. Morris, M. Baker, K. Yasojima, H. Houlden, M. N. Khan, N. W. Wood, J. Hardy, M. Grossman, J. Trojanowski, T. Revesz, E. H. Bigio, C. Bergeron, J. C. Janssen, P. L. McGeer, M. N. Rossor, A. J. Lees, P. L. Lantos, M. Hutton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.

Original languageEnglish (US)
Pages (from-to)443-445
Number of pages3
Issue number3
StatePublished - Aug 13 2002

ASJC Scopus subject areas

  • Clinical Neurology


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