Analysis of tau haplotypes in Pick's disease

H. R. Morris; M. Baker; K. Yasojima; H. Houlden; M. N. Khan; N. W. Wood; J. Hardy; M. Grossman; J. Trojanowski; T. Revesz; E. H. Bigio; C. Bergeron; J. C. Janssen; P. L. McGeer; M. N. Rossor; A. J. Lees; P. L. Lantos; M. Hutton

doi:10.1212/WNL.59.3.443

Analysis of tau haplotypes in Pick's disease

H. R. Morris, M. Baker, K. Yasojima, H. Houlden, M. N. Khan, N. W. Wood, J. Hardy, M. Grossman, J. Trojanowski, T. Revesz, E. H. Bigio, C. Bergeron, J. C. Janssen, P. L. McGeer, M. N. Rossor, A. J. Lees, P. L. Lantos, M. Hutton^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.

Original language	English (US)
Pages (from-to)	443-445
Number of pages	3
Journal	Neurology
Volume	59
Issue number	3
DOIs	https://doi.org/10.1212/WNL.59.3.443
State	Published - Aug 13 2002

Funding

ASJC Scopus subject areas

Clinical Neurology

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10.1212/WNL.59.3.443

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title = "Analysis of tau haplotypes in Pick's disease",

abstract = "Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.",

author = "Morris, {H. R.} and M. Baker and K. Yasojima and H. Houlden and Khan, {M. N.} and Wood, {N. W.} and J. Hardy and M. Grossman and J. Trojanowski and T. Revesz and Bigio, {E. H.} and C. Bergeron and Janssen, {J. C.} and McGeer, {P. L.} and Rossor, {M. N.} and Lees, {A. J.} and Lantos, {P. L.} and M. Hutton",

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T1 - Analysis of tau haplotypes in Pick's disease

AU - Morris, H. R.

AU - Baker, M.

AU - Yasojima, K.

AU - Houlden, H.

AU - Khan, M. N.

AU - Wood, N. W.

AU - Hardy, J.

AU - Grossman, M.

AU - Trojanowski, J.

AU - Revesz, T.

AU - Bigio, E. H.

AU - Bergeron, C.

AU - Janssen, J. C.

AU - McGeer, P. L.

AU - Rossor, M. N.

AU - Lees, A. J.

AU - Lantos, P. L.

AU - Hutton, M.

PY - 2002/8/13

Y1 - 2002/8/13

N2 - Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.

AB - Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau H1 haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.

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JO - Neurology

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Analysis of tau haplotypes in Pick's disease

Abstract

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ASJC Scopus subject areas

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