Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups

S. Gong; L. Gao; X. Qian; T. Tian; W. Chen

doi:10.1007/bf02900654

Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups

S. Gong, L. Gao, X. Qian, T. Tian, W. Chen^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A mouse chemokine MIP-2 (macrophage inflamatory protein 2) is constitutively expressed not only by peritoneal macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes in different degrees, it mainly chemoattract the DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.

Original language	English (US)
Pages (from-to)	1694-1698
Number of pages	5
Journal	Chinese Science Bulletin
Volume	46
Issue number	20
DOIs	https://doi.org/10.1007/bf02900654
State	Published - 2001

Funding

Acknowledgements This work was supported by the International

Keywords

Chemotactic activity
Macrophage inflamatory protein 2
Thymocytes

ASJC Scopus subject areas

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10.1007/bf02900654

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title = "Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups",

abstract = "A mouse chemokine MIP-2 (macrophage inflamatory protein 2) is constitutively expressed not only by peritoneal macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes in different degrees, it mainly chemoattract the DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.",

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volume = "46",

pages = "1694--1698",

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TY - JOUR

T1 - Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups

AU - Gong, S.

AU - Gao, L.

AU - Qian, X.

AU - Tian, T.

AU - Chen, W.

N1 - Funding Information: Acknowledgements This work was supported by the International

PY - 2001

Y1 - 2001

N2 - A mouse chemokine MIP-2 (macrophage inflamatory protein 2) is constitutively expressed not only by peritoneal macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes in different degrees, it mainly chemoattract the DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.

AB - A mouse chemokine MIP-2 (macrophage inflamatory protein 2) is constitutively expressed not only by peritoneal macrophages, but also by fresh thymic stromal cells, based on RT-PCR detection. Moreover, the specific receptor of MIP-2 is expressed at different levels among four main subgroups of murine thymocytes including DN, DP, CD4SP and CD8SP. By the chemotaxis assays with Boyden chamber, we proved that the recombinant mouse MIP-2 can chemoattract the four main subgroups of thymocytes in different degrees, it mainly chemoattract the DP and SP subgroups. We firstly reported that MIP-2 is involved in the regulation of the directional migration of developing thymocytes.

KW - Chemotactic activity

KW - Macrophage inflamatory protein 2

KW - Thymocytes

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Analysis of the chemotactic activities of mouse chemokine MIP-2 to thymocyte subgroups

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