Analytical description of extension, torque, and supercoiling radius of a stretched twisted DNA

Sébastien Neukirch*, John F. Marko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

We study the mixture of extended and supercoiled DNA that occurs in a twisted DNA molecule under tension. Closed-form asymptotic solutions for the supercoiling radius, extension, and torque of the molecule are obtained in the high-force limit where electrostatic and elastic effects dominate. We demonstrate that experimental data obey the extension and torque scaling laws apparent in our formulas, in the regime where thermal fluctuation effects are quenched by applied force.

Original languageEnglish (US)
Article number138104
JournalPhysical review letters
Volume106
Issue number13
DOIs
StatePublished - Apr 1 2011

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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